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Santu Bera

Faculty Fellow, Ramanujan Fellow of Chemistry, Ashoka University

Ph.D. Indian Institute of Science Education and Research, Kolkata

After completing his B.Sc and M.Sc from Vidyasagar University, West Bengal, Santu joined the Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER)-Kolkata for pursuing his doctoral study under the supervision of Prof. Debasish Haldar. Santu’s doctoral research focused on the molecular self-assembly of biological and bio-inspired organic building blocks into novel architectures with fascinating functionalities. After finishing his Ph.D. in 2016 and a short stay in the same group as a postdoctoral fellow, he moved to Israel. Santu has had the great privilege to work with Professor Ehud Gazit for several years as a Postdoctoral Research Fellow in the Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University. He used the concept of the “reductionist approach” to define the minimal modules that promote molecular recognition and drives the assembly processes into diverse nanostructures mimicking the living systems. Such remarkably simple building motifs combine the advantages of small molecules such as easy synthesis at low cost and complex properties of natural proteins. The discovery of minimal biomimetic materials endows with exciting functionalities like ultra-rigidity, and efficient piezoelectric properties comparable to Pb-based inorganic materials. In a continuous position in the Department of Oral Biology, The Goldschleger School of Dental Medicine, Tel Aviv University under the supervision of Prof. Lihi Adler-Abramovich, he explored the potential of minimal collagen mimetic peptide-based composite materials for biomedical applications. In 2021, Santu was awarded the highly prestigious Marie-Sklodowska Curie fellowship by the European Research Council (ERC) and joined Prof. Gilles Guichard’s peptidomimetic chemistry lab in the Institut Européen de Chimie et Biologie (IECB), Université de Bordeaux, France. Santu was awarded the Ramalingaswami Re-entry Fellowship by the Department of Biotechnology, Govt. of India in 2022 and the Ramanujan Fellowship from SERB, Govt. of India in 2023. In May 2023, Santu joined the Department of Chemistry, at Ashoka University as a Faculty Fellow.

Santu’s current research interest at Ashoka University is the development of bio-inspired smart materials for nanotechnology. As we know, nature capitalizes on self-assembly to convert chemically simple building blocks into sophisticated materials that function cooperatively in living systems. The backbone conformation and 2D, 3D structure in space of natural components is the key factor behind their specific functions. We would aim to develop artificial biomimetic systems that mimic nature structurally and functionally for emerging applications in diverse areas like green energy harvesting, bioelectricity for disease treatment, catalysis, selective encapsulation, and so on.

  1. Santu Bera, Pierre-Andre Cazade, Shayon Bhattacharya, Sarah Guerin, Moumita Ghosh, Francesca Netti, Damien Thompson and Lihi Adler-Abramovich, Molecular Engineering of Rigid Hydrogels Co-assembled from Collagenous Helical Peptides Based on a Single Triplet Motif, ACS Appl. Mater. Interfaces 2022, 14, 46827-46840.
  2. Santu Bera, Sarah Guerin, Hui Yuan, Joseph O’Donnell, Nicholas P. Reynolds4, Oguzhan Maraba, Wei Ji, Linda J. W. Shimon, Pierre-Andre Cazade, Syed A. M. Tofail, Damien Thompson, Rusen Yang and Ehud Gazit, Molecular Engineering of Piezoelectricity in Collagen-Mimicking Peptide Assemblies, Nat. Commun. 2021, 12, 1-12.
  3. Santu Bera, Bin Xue, Pavel Rehak, Guy Jacoby, Wei Ji, Linda J. W. Shimon, Roy Beck, Petr Král, Yi Cao, and Ehud Gazit, Self-Assembly of Aromatic Amino Acid Enantiomers into Supramolecular Materials of High Rigidity, ACS Nano, 2020, 14, 2, 1694–1706.
  4. Santu Bera, Sudipta Mondal, Bin Xue, Linda J. W. Shimon , Yi Cao , and Ehud Gazit, Rigid helical-like assemblies from a self-aggregating tripeptide, Nat. Mater. 2019, 18, 503-509.
  5. Santu Bera, Sudipta Mondal, Yiming Tang, Guy Jacoby, Elad Arad, Tom Guterman, Raz Jelinek, Roy Beck, Guanghong Wei, and Ehud Gazit, Deciphering the Rules for Amino Acid Co-Assembly Based on Interlayer Distances, ACS Nano, 2019, 13, 1703–1712.
  6. Santu Bera, Sudipta Mondal, Sigal Rencus-Lazar, and Ehud Gazit, Organization of Amino Acids into Layered Supramolecular Secondary Structures, Acc. Chem. Res., 2018, 51, 2187–2197.
  7. Santu Bera and Debasish Haldar, Rechargeable self-healing safety fuel gel, J. Mater. Chem. A, 2016, 4, 6933.
  8. Priyadarshi Chakraborty, Santu Bera, Phil Mickel, Ashim Paul, Linda J. W. Shimon, Zohar A. Arnon, Daniel Segal, Petr Král and Ehud Gazit, Inhibitor-Mediated Structural Transition in a Minimal Amyloid Model, Angew. Chem. Int. Ed., 2021, 60, e202113845.
  9. Dorin Sade Yazdi, Dana Laor, HanaaAdsi, Shira Shaham Niv, Santu Bera, Shahaf Sigal, Dor Zaguri, Damilola Oluwatoba, Davide Levy, Thanh Do, Dan Frenkel and Ehud Gazit, Homocysteine fibrillar assemblies display metabolite-protein cross-talk, Proc. Natl. Acad. Sci. U.S.A., 2021, 118, e2017575118.
  10. Vasantha Basavalingappa, Santu Bera, Bin Xue, IdoAzuri, Yiming Tang, Kai Tao, Linda J. W. Shimon, Michael R. Sawaya, Sofiya Kolusheva, David S. Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei and Ehud Gazit, Mechanically Rigid Supramolecular Assemblies Formed by Fmoc-Conjugated Guanine Peptide Nucleic Acid, Nat. Commun, 2019, 10, 5256.

 

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